现代检验医学杂志Issue(1)：19-22,4.DOI:10.3969/j.issn.1671-7414.2015.01.006
β2 GPⅠ及其抗体与抗磷脂综合征的研究进展
Research Progress ofβ2 GlycoproteinⅠ and Anti-β2GPⅠ Antibodies and Antiphospholipid Syndrome
摘要
Abstract
Antiphospholipid syndrome (APS)is an autoimmune multisystem disorder characterized clinically by recurrent thrombosis and pregnancy morbidity.β2-glycoproteinⅠ (β2GPⅠ)is the major antigen in the APS.Anti-β2GPⅠ antibody is the autoantibody which targets toβ2GPⅠ.There is overwhelming evidence thatβ2GPⅠand anti-β2GPⅠ antibody play an important role in the pathogenesis of APS.Now the diagnosis and treatment of anti-β2GPⅠ antibody are more and more get people's attention,detection of anti-β2GPⅠDⅠ antibody can specifically diagnose APS and research of the molecular level may provide a new therapeutic target for APS.In this paper,β2GPⅠ,anti-β2GPⅠ antibody and APS associated development were reviewed.关键词
β2糖蛋白Ⅰ/抗β2GPⅠ抗体/抗磷脂综合征Key words
β2-glycoproteinⅠ/anti-β2GPⅠantibody/antiphospholipid syndrome分类
医药卫生引用本文复制引用
孙娜,张文静,高飞,刘彦虹..β2 GPⅠ及其抗体与抗磷脂综合征的研究进展[J].现代检验医学杂志,2015,(1):19-22,4.基金项目
国家自然科学基金（编号81270394）。 （）
