现代检验医学杂志Issue(2)：1-2,6,3.DOI:10.3969/j.issn.1671-7414.2015.02.001
锰超氧化物歧化酶9 Ala／Val 基因多态性对冠心病的影响
Effects of Manganese Superoxide Dismutase 9 Ala/Val Genetic Polymorphisms on Coronary Heart Disease
摘要
Abstract
Objective To study associations between manganese superoxide dismutase 9 Ala/Val (Mn-SOD 9 Ala/Val)genet-ic polymorphism and total superoxide dismutase (T-SOD)and Mn-SOD activity and the impact on coronary heart disease (CHD)were studied.Methods There were 82 CHD patients and 57 controls in this research.Sequencer was used to identify the genotype of Mn-SOD 9 Ala/Val genetic polymorphism and colorimeter was used to detect the serum T-SOD and Mn-SOD activity.Results Compared with the control group,the serum T-SOD and Mn-SOD activity of the CHD group was significantly reduced(t=4.83,6.57,P all<0.05),while the VV genotype and V allele of Mn-SOD 9 Ala/Val genetic poly-morphism of the CHD group were higher (χ2 =4.75,P <0.05).The serum T-SOD and Mn-SOD activity of the Mn-SOD 9 VV genotype was significantly lower than the Mn-SOD 9 AA genotype(t=2.96,3.11,P all<0.05).Conclusion The ser-um T-SOD and Mn-SOD activity in the CHD patients was reduced.Mn-SOD 9 Ala/Val genetic polymorphism was involved in the pathogenesis of CHD by influencing the Mn-SOD activity.关键词
锰超氧化物歧化酶/冠心病/基因多态性Key words
manganese superoxide dismutase (Mn-SOD)/coronary heart disease (CHD)/genetic polymorphism分类
医药卫生引用本文复制引用
姚创利,赵佳,黎阳,黎波,陆华,白妮,刘琳,辛渭川,姜小建..锰超氧化物歧化酶9 Ala／Val 基因多态性对冠心病的影响[J].现代检验医学杂志,2015,(2):1-2,6,3.基金项目
陕西省科学技术研究发展计划项目（项目编号2013K12-02-10）。 （）
