现代检验医学杂志Issue(3)：13-16,4.DOI:10.3969/j.issn.1671-7414.2015.03.004
CHB 患者疾病进程与抑郁症的程度及血清 BDNF 水平的相关性
Correlation of the Disease Process,Depression Severity and Serum Levels of BDNF in Patient with CHB
摘要
Abstract
Abatract:Objective To study the relationship of the processes of chronic hepatitis B infection with the degree of depression and the level of serum Brain-derived neurotrophic factor (BDNF).Methods 126 patients with different processes of CHB infection were divided into 3 groups,which were asymptomatic HBV carriers (ASC group),liver cirrhosis (LC group)and hepatic cell carcinoma (HCC group).40 healthy volunteers were selected as normal control.Questionnaire was used to study demographic data and the degree of depression was assessed by using Hamilton Depression Rating Scale (HAMD-17).The levels of the serum BDNF were detected by ELISA.Results The ratio of divorced or widowed in LC and HCC groups was higher than that of the control (χ2 = 6.354,11.972;P < 0.01).Severity of depression in ASC,LC and HCC groups was higher than that of the control (χ2 = 16.151,42.150,49.636;P <0.01).Severity of depression in ASC and LC group was lower than that of HCC group (χ2 = 14.345,28.772;P <0.01).The role of BDNF (x ±s,ng/ml)in ASC,LC,HCC and control group were 11.10±3.26,8.66 ± 3.11,7.39 ±2.52 and 12.18±2.59.The levels of serum BDNF in LC and HCC group was lower than ASC group and the control (P <0.01).The process of CHB infection had positive correlation with the score of HAMD (r=0.719,P <0.01),but had negative correlation with thelevels of serum BDNF (r=-0.504,P <0.01). There was negative correlation relationship between the score of HAMD and the levels of serum BDNF (r=-0.526,P <0.01).Conclusion The process of CHB infection can obviously aggravate the degree of depression,and reduce the levels of BDNF gradually.The levels of serum BDNF can be suggested as a psychological laboratory reference basis for the CHB pa-tients with depression.It is expected to improve the level of clinical diagnosis and treatment in CHB with depression.关键词
慢性乙型肝炎/抑郁症/脑源性神经营养因子Key words
chronic hepatitis B/depression/brain-derived neurotrophic factor分类
医药卫生引用本文复制引用
惠凌云,王凌,张琳,冯艾,李娜,李义平,王亚文..CHB 患者疾病进程与抑郁症的程度及血清 BDNF 水平的相关性[J].现代检验医学杂志,2015,(3):13-16,4.基金项目
国家自然科学基金资助，项目批准号81101260。 （）
