陕西医学杂志Issue(5)：526-528,3.DOI:10.3969/j.issn.1000-7377.2014.05.004
脑缺血再灌注后大鼠运动皮质SIRT3的表达特点
Expression of SIRT3 in the cerebral motor cortex of rats following cerebral ischemic reperfusion
摘要
Abstract
Objective:To observe the changes in the expression of silent information regulator 3 (SIRT3 ) in the cerebral motor cortex of rats following global cerebral ischemic reperfusion .Methods:The cerebral tissues were collected from rats following global cerebral ischemic reperfusion at time point of 6h ,24h ,72h ,5d ,and 7d (7 in each group) ,and the expression of SIRT3 in the cerebral cortex was detected by immunohistochemistry .Results :Under optical microscope ,SIRT3-positive cells were found in every group .Within the time range of 6h ,24h and 72h following global cerebral ischemic reperfusion ,SIRT3-positive cells increased significantly (P<0 .01) ,but within the time range of 72h ,5d and 7d ,the number of SIRT3-positive cells reduced significantly (P<0 .01) .Conclusion :The parabola-like change of SIRT3 expression time-phase in the cerebral cortex indicate that SIRT 3 might be related to pathophysiological processes of cerebral ischemic reperfusion .关键词
缺氧缺血 ,脑/病理生理学/再灌注/信息素类/代谢/大鼠/沉默信息调节因子3Key words
Hypoxia-ischemia/brain/physiopathology/Reperfusion/Pheromones/metabolism/Rats Silent information regulator3分类
医药卫生引用本文复制引用
常明则,吴海琴,乔琳,王新来,狄政莉,刘志勤,毛佳,田晔..脑缺血再灌注后大鼠运动皮质SIRT3的表达特点[J].陕西医学杂志,2014,(5):526-528,3.基金项目
国家自然科学基金面上项目（81270415）；陕西省卫生厅科研基金（2012D43）；西安市科技计划项目（SF1319（2）） （）
