陕西医学杂志Issue(6)：723-725,3.DOI:10.3969/j.issn.1000-7377.2014.06.040
血小板活化功能对2型糖尿病患者颈动脉粥样硬化的影响
Relationship between Platelet activating function and carotid atherosclerosis in type 2 diabetes
摘要
Abstract
Objective :To study the relationship between platelet activation function and carotid athero-sclerosis in type 2 diabetes mellitus ,and the correlation with blood sugar level .Methods:234 type 2 diabetes were re-cruited ,blood sugar level were evaluated .Measurement of carotid intima-media thickness was performed with color Doppler apparatus ,they were divided into CAS group (102) ,and no CAS group (132) .Will be according to the de-termination of glycosylated hemoglobin level in patients with CAS group divided into good blood sugar control (HbA1C<7% ,42) ,poor control of blood sugar group (HbA1C>7% ,60) .Application of flow cytometry instru-ment technology determination of CAS and no CAS group different glucose control level of platelet activating func-tion related indicators :CD62p ,CD63 ,and CD41/CD61 .Results :In patients with type 2 diabetes complicated with CAS group of platelet CD62p ,CD63 and CD41/CD61 no CAS patients significantly increased (P<0 .01) ,and was significantly associated with blood sugar levels ,expression of CD62p ,CD63 and CD41/CD61 in HbA1C level<7% of patients group with CAS group were compared with HbA 1C>7% group significantly decreased ,and there were sta-tistically significant differences (P<0 .01) .Conclusion:Platelet activating function index (CD62p ,CD63 and CD41/CD61) obviously increased in patients with type 2 diabetes complicated with CAS ,and blood sugar level were signifi-cantly related ;In patients with type 2 diabetes complicated with CAS and poor blood glucose control in patients with early positive control blood sugar ,antiplatelet therapy ,prevent disease of heart head blood-vessel .关键词
糖尿病 ,2型/动脉粥样硬化/血小板活化Key words
Diabetes mellitus ,type 2/Atherosclerosis/Platelet activation分类
医药卫生引用本文复制引用
李晓燕,郭剑,李辉,董春萍,王养维..血小板活化功能对2型糖尿病患者颈动脉粥样硬化的影响[J].陕西医学杂志,2014,(6):723-725,3.基金项目
陕西省青年科学基金项目 （）
