陕西医学杂志Issue(7)：771-773,778,4.DOI:10.3969/j.issn.1000-7377.2014.07.001
高脂高糖饮食对家兔糖耐量影响实验研究
High fat-sucrose diet effect on glucose tolerance of rabbits
摘要
Abstract
Objective :To induce metabolic syndrome in Japanese white rabbit by high fat/high sucrose diet (HFSD) .Methods:Twenty male Japanese white rabbits were divided into 2 groups by randomized block de-sign :normal diet group (n=10) and HFSD group (n=10 ,with 10 % lard ,30 % white cane sugar and 60 % nor-mal fodder) ,and observed for 36 weeks .The blood samples of the rabbits were tested for the levels of plasma glu-cose and triglyceride after overnight fasting every two weeks .At the end of 36th week ,after intravenous glucose tol-erance test (IVGTT) ,all the rabbits were killed to observe vital organs and weight all adipose tissues .Results:The difference between the 2 groups was not significant in plasma glucose ,triglyceride and insulin except in IVGTT . HFSD group were higher in body weight [(3 .90 ± 0 .09) kg vs (3 .18 ± 0 .27) kg] and adipose tissue [total adipose tissue:(493 .40 ± 55 .25) g vs (331 .45 ± 38 .28) g ;visceral adipose tissue :(354 .90 ± 48 .18) g vs (214 .35 ± 23 .74) g] as compared with control group ,and the difference was significant .Conclusion:HFSD can induce impaired glu-cose tolerance and trend of central obesity in Japanese white rabbits .关键词
肥胖症/病理生理学/葡萄糖代谢障碍/代谢/模型 ,动物/葡糖耐量试验/家兔Key words
Obesity/Physiopathology/Glucose metablism disorders/Metabolism/models ,animal/Glu-cose tolerance text/Rabbits分类
医药卫生引用本文复制引用
张光伟,林燕,朱宁红,白艳萍,杨佩刚,刘恩岐..高脂高糖饮食对家兔糖耐量影响实验研究[J].陕西医学杂志,2014,(7):771-773,778,4.基金项目
国家自然科学基金项目（81070250）陕西省公共平台建设基金项目 （）
