陕西医学杂志Issue(7)：790-792,3.DOI:10.3969/j.issn.1000-7377.2014.07.007
自体外周血干细胞移植治疗乙型肝炎肝硬化失代偿期38例
The efficacy of autologous peripheral blood stem cell transplantation treating 38 case of patients with decompensated hepatitis B liver cirrhosis
摘要
Abstract
Objective :To observe the efficacy of autologous peripheral blood stem cell transplantation treating patients with decompensated hepatitis B liver cirrhosis .Methods :58 patients with decompensated hepatitis B liver cirrhosis were randomly divided into observation group (n=38) and control group(n=20) .The control group were given basic treatment ,the observation group were treated with autologous peripheral blood stem cell transplan-tation and followed twenty-four weeks ,the changs of serum albumin(ALB) ,total bilirubin(TBIL) ,prothrombin time(PT ) and clinical symptoms were observed before and after treatment .Results :The levels of ALB、TBIL and PT in control group after treatment had no statistical difference compared with pro-treatment .Comapred with pro-treatment ,the level of ALB in observation group increased significantly after treated twelve weeks and twenty-four weeks while the level of TBIL and PT decreased significantly .All indexes after treated twelve weeks and twenty-four weeks had statistical difference between contol group and observation group .The improved rate of bloating ,appe-tite ,fatigue and ascites were 50 .00% 、40 .00% 、55 .00% and 50 .00% respectively after treated for eight weeks ,the observation group were 84 .21% 、78 .95% 、86 .84% and 92 .00% respectively ,the two groups had statistical differ-ence on the improvement of bloating ,appetite ,fatigue and ascites .Conclusion:Autologous peripheral blood stem cell transplantation treating for patients with decompensated hepatitis B liver cirrhosis is safe ,effective and has little side effects ,it can be used as clinical treatment for patients with hepatitis B liver cirrhosis .关键词
乙型肝炎/并发症/肝硬化/治疗/外周血干细胞移植/方法/移植 ,自体Key words
Hepatitis/Complications/Liver cirrhosis/Therapy/Peripheral blood stem cell transplanta-tion/method/T ransplantation ,autologous分类
医药卫生引用本文复制引用
赵文轩,张瑞娟,刘海玲,聂青和,刘小莹,郑宏波,吕宽厚,魏娜..自体外周血干细胞移植治疗乙型肝炎肝硬化失代偿期38例[J].陕西医学杂志,2014,(7):790-792,3.基金项目
陕西省科学技术研究发展计划项目 （）
