陕西医学杂志Issue(5)：521-523,3.DOI:10.3969/j.issn.1000-7377.2015.05.003
脂氧素受体激动剂BML-111对野百合碱诱导肺动脉高压大鼠肺动脉压力及机制的研究
The effect of lipoxin receptor agonist BML-111 on rats pulmonary arterial hypertension and mechanisms induced by monocrotaline
摘要
Abstract
Objective :To observe the the effect of BML‐111 on pulmonary arterial hypertension induced by monocrotaline and potential mechanisms .Methods :24SD rats randomly divided into three groups :C group ,PH group and B group ,Both PH group and B group processed subcutaneous injection of 50ug /g monocrotaline while C group received same volume of saline ,B group performed intraperitoneal injection of BML‐111 1mg ・ kg‐1 ・ d‐1 from the day when monocrotaline was injected .The observation :MPAP ,RVSP ,RV /(LV + S) ,the concentration of en‐dotheline(ET ) and tumor necrosis factor α(TNFα) in the plasma .Results :the PH group and B group had higher level of MPAP ,RVSP ,RV /(LV + S) ,the plasma concentration of ET and TNFαcompared with C group(P < 0 . 05) ,B group caused lower increase of MPAP , RVSP , RV/(LV + S ) , the plasma concentration of ET and TNFαcompared with PH group(P < 0 .05) .Conclusion :BML‐111 can ameliorate pulmonary arterial hypertension , part of the reason may be attribute to the reduction the inflammation and decreasing the pulmonary arterial remode‐ling .关键词
高血压,肺性/病理生理学/野百合碱/化学诱导/模型,动物/大鼠Key words
Hypertension,pulmonary/physiopathology/Monocrotaline/chemically induced/Models,an-imal/Rats分类
医药卫生引用本文复制引用
陈永梅,龚兴瑞,向勇,秦成名..脂氧素受体激动剂BML-111对野百合碱诱导肺动脉高压大鼠肺动脉压力及机制的研究[J].陕西医学杂志,2015,(5):521-523,3.基金项目
湖北省十堰市科技局指导项目 （）
