实用肝脏病杂志Issue(4)：376-379,4.DOI:10.3969/j.issn.1672-5069.2014.04.011
慢性HBV携带孕妇产后自发HBeAg和HBsAg血清清除或转换的病毒学因素分析
Virologic determinants of postpartum spontaneous HBeAg and/or HBsAg seroclearance or seroconver-sion in pregnant women who are chronic hepatitis B virus carriers
摘要
Abstract
Objective To study the virologic determinants of spontaneous seroclearance or seroconversion of HBeAg and/or HBsAg in pregnant women who are chronic hepatitis B virus (HBV) carriers. Methods The pregnant women diagnosed as chronic HBV carriers between August,2002 and July,2004 were included and fol-lowed up between October,2009 and March,2010. The HBV serologic markers and HBV DNA were detected. Results A total of 419 individuals were recruited in this study,and the average follow-up period was 6.4 years. Although 155 women lost,a total of 264(63.0%) women were successfully followed up,of whom 76 (28.8%) were HBeAg-positive at presentation. 55.3%(42/76) of HBeAg-positive women were seroconverted to anti-HBe sponta-neously at the follow-up. Compared with 34 women without seroconversion,42 with HBeAg/anti-HBe seroconver-sion had lower levels of serum HBV DNA,HBeAg and HBsAg(all P﹤0.01). The postpartum HBeAg seroconversion rate in 6 pregnant women with HBV DNA ﹤1×106 IU/ml,17 with HBeAg ﹤700 S/CO,and 13 with HBsAg﹤1×104 IU/ml were 100.0%,100.0% and 92.3%,respectively. The spontaneous HBsAg seroclearance was found in 38 (14.4%) women at the follow-up. The serum HBsAg levels at presentation were significantly lower in women with HBsAg seroclearance than 226 without HBsAg seroclearance (P﹤0.001). The postpartum HBsAg seroclearance rate in 25 pregnant women with HBsAg ﹤100 IU/ml was as high as 56.0%. Conclusions HBeAg-positive women with serum HBV DNA ﹤1 ×106 IU/ml,HBeAg ﹤700 S/CO and/or HB-sAg ﹤1×104 IU/ml are more likely to undergo spontaneous HBeAg seroconversion,and those with serum HBsAg ﹤100 IU/ml have a higher chance of spontaneous HBsAg sero-clearance.关键词
乙型肝炎病毒携带者/孕妇/HBeAg血清学转换/HBsAg血清学清除Key words
Hepatitis B virus carrier/Pregnant women/HBeAg seroconversion/HBsAg seroclearance引用本文复制引用
冯振华,张姝,刘景丽,毕永春,夏挺,许碧云,胡娅莉,周乙华..慢性HBV携带孕妇产后自发HBeAg和HBsAg血清清除或转换的病毒学因素分析[J].实用肝脏病杂志,2014,(4):376-379,4.基金项目
南京市第一层次卫生人才项目（编号2011024）；南京大学医学院附属鼓楼医院青年科研启动基金 （）
