摘要
Abstract
To investigate the effects of astaxanthin on chronic liver injury in rats and to explore the underlying mechanism. Methods Chronic liver injury in rats were induced by carbon tetrachloride injection, and the rats were randomly divided into control,model and astaxanthin group. The content of ALT,AST,ALP,TP in serum and superoxide dismutase (SOD),glutathione-S-transfcrase (GST),glutathione (GSH) and malondialde-hyd (MDA) in liver tissues were detected. The collagensⅠmRNA were detected by RT-PCR. Results The colla-gens index in model group were (1.84±0.24),much higher than in control [(0.42±0.12),P﹤0.05],while the colla-gens index in astaxanthin group (0.89±0.12) decreased significantly (P﹤0.05) as compared to that in the model;The collagenⅠmRNA in model group (0.48±0.06) was higher than in control group (0.12±0.02),while it de-creased (0.35±0.09) in astaxanthin group (P﹤0.01) as compared to that in the model;In control group,the MDA, GST,GSH and SOD in liver tissues were (1.93±0.76) nmol/mg, (18.43±5.34) U/mg,(75.45±9.67) mg/g and (678.80±76.56) U/mg,respectively. They were (6.56±1.09) nmol/mg,(54.34±7.65) U/mg,(35.45±9.01) mg/g and (203.89±89.00 U/mg),respectively. After treatment of astaxanthin,they were(3.34±1.12) nmol/mg,(30.89±4.78) U/mg,(56.78±7.78) mg/g and (432.34±92.56 U/mg),respectively. Conclusion Astaxanthin could attenuate chronic liver injury in rats by improving the anti-oxidative stress.关键词
慢性肝损伤/虾青素/氧化应激/保护作用Key words
Chronic liver injury/Astaxanthin/Protective effect/Oxidative stress
