实用肝脏病杂志Issue(5)：546-549,4.DOI:10.3969/j.issn.1672-5069.2014.05.029
NLRP3炎症小体在肝脏疾病发病中的作用研究进展
What roles the NLRP3 play in liver diseases
摘要
Abstract
The inflammasome is a sort of multiprotein complexes in the cytoplasm,acting as an important component of the body’s innate immune. The nucleotide-binding oligomerization domain(NOD)-like receptors(NLRs),for example the NLRP3, mainly consists of NLRP3,apoptosis-associated speck-like protein (ASC)and cysteinyl aspartate specific proteinase (Caspase-1), which plays a vital roles in the immune regulation and antimicrobial activities. In recent years,there has been a growing number of evidence indicating that NLRP3,the inflammasome,may be closely associated with all kinds of liver diseases. The activation pathway,regulatory mechanism of NLRP3 and its relationship with liver diseases were reviewed .关键词
肝疾病/炎症小体/核苷酸结合寡聚化结构域样受体家族Key words
Liver diseases/Inflammasome/NLRP3引用本文复制引用
王晓彤(综述),韩涛(审校)..NLRP3炎症小体在肝脏疾病发病中的作用研究进展[J].实用肝脏病杂志,2014,(5):546-549,4.基金项目
天津市科委基金项目（编号13RCGFSY19200）；国家科技第十二五重大专项(编号2012ZX10002004-011) （编号2012ZX10002004-011）
