实用肝脏病杂志Issue(6)：579-582,4.DOI:10.3969/j.issn.1672-5069.2014.06.006
外周血DNT细胞和T细胞亚群检测在乙型肝炎病毒感染者诊断中的意义
Changes of peripheral blood double negative T cells and T cell subsets in patients with hepatitis B virus infection
摘要
Abstract
Objective To investigate the changes of peripheral blood CD3 +CD4 -CD8 -T cells (double negative T,DNT) and T lymphocyte subsets in patients with hepatitis B virus (HBV) infection. Methods The peripheral blood DNT cells and T lymphocyte subsets were detected by flow cytometry in 136 HBV cases including asymptomatic carriers (ASCs,n=33),acute hepatitis B (AHB,n=28),mild chronic hepatitis B (n=28), moderate chronic hepatitis B(n=25),severe chronic hepatitis B(n=22) and healthy persons(n=39). Results The percentages of DNT cells in healthy persons and in patients with AHB were (4.82 ±3.43)% and (4.75 ±2.71)%, respectively,both of which were significantly lower than that in ASCs [(5.43 ±3.31)%,P<0.05];The percentage of DNT cells in patients with mild CHB was (7.97 ±4.12)%, significantly lower than in patients with severe CHB [(11.36±5.01)%,P<0.05],and the percentage of DNT cells in patients with moderate CHB was (8.41±4.93)%,also significantly lower than in patients with severe CHB (P<0.05);There were no differences in percentages of T lymphocyte subsets among health persons,patients with acute hepatitis B and ASCs;The percentages of CD3+ and CD3+CD4+CD8- cells decreased(P<0.05) and the percentage of CD3+CD4-CD8+ cells increased (P<0.05) in patients with chronic severe hepatitis B. Conclusions The increase in peripheral blood DNT cells is associated with the chronicity of illness in patients with CHB.关键词
慢性乙型肝炎/CD3+CD4-CD8-T细胞/T淋巴细胞亚群Key words
Chronic hepatitis B/CD3+CD4-CD8-T cell/T lymphocyte subsets引用本文复制引用
杜振华,鲍布和,王仁杰,任党利,张明华,刘冀琴..外周血DNT细胞和T细胞亚群检测在乙型肝炎病毒感染者诊断中的意义[J].实用肝脏病杂志,2014,(6):579-582,4.基金项目
武警后勤学院附属医院院内基金项目 （）
