实用肝脏病杂志Issue(6)：661-664,4.DOI:10.3969/j.issn.1672-5069.2014.06.028
PD-1/PD-L1信号通路与慢性乙型肝炎
PD-1/PD-L signal pathway in chronic hepatitis B
摘要
Abstract
Programmed death-1(PD-1) is an important coordinated stimulus molecule belonging to the B7/CD28 family. When it combines with its ligand programmed death ligand (PD-L),can regulate the activation,differentiation and multiplication of T lymphocytes. PD-1 expression in different stages of chronic HBV infection varies ,and is closely related to the degree of liver inflammation,ALT levels and viral loads. Through different ways to block the PD-1/PD-L1 pathway can improve the function of T lymphocytes,and it might be one of the direction for antiretroviral treatment in the future.关键词
慢性乙型肝炎/程序性死亡分子-1/程序性死亡分子-1配体/T淋巴细胞Key words
Hepatitis B/Programmed death-1/Programmed death -1 ligand/T lymphocytes引用本文复制引用
万和荷(综述),刘丽丽,侯勇,张国梁(审校)..PD-1/PD-L1信号通路与慢性乙型肝炎[J].实用肝脏病杂志,2014,(6):661-664,4.基金项目
安徽省自然基金项目 （）
