实用肝脏病杂志Issue(1)：34-37,4.DOI:10.3969/j.issn.1672-5069.2015.01.009
住院患者药物性肝损伤病因分析及熊去氧胆酸协同治疗疗效观察
Common agents in patients with drug-induced liver injury and observation of therapeutic efficacy of ursodeoxycholic acid
施慧 1魏娟 1王震凯 1王少东 1杨妙芳 1路又可 1刘炯 1汪芳裕1
作者信息
- 1. 210000 南京市 南京军区南京总医院消化内科
- 折叠
摘要
Abstract
Objective To investigate the common agents related to drug-induced liver injury (DILI) in our hospitalized patients and to observe the clinical efficacy of ursodeoxycholic acid in treatment of patients with DILI. Methods Two hundred patients with DILI were recruited in this study and the common agents were analyzed. The patients were divided into two groups. Patients in control group received magnesium isoglycyrrhizinate , glu-tathione and polyene phosphatidylcholine(one,two,and all or any combination of them) for four weeks. Ademetio-nine was given when hyperbilirubinemia appeared. The patients in observation group received additionally ur-sodeoxycholic acid for four weeks at the base treatment in the control. Results The leading agents in our pa-tients with DILI were immunosuppressive agents(34.0%),followed by traditional Chinese medicin(28.5%),and oth-er common agents were antibacterial (13.0%),antitubercular agents (7.5%), chemotherapeutics (7.5%),and an-tipyretic analgesics (4.5%). Liver function improved in both groups after four week treatment,while the efficacy was superior in ursodeoxycholic acid-treated patients (P<0.01). Conclusion Immunosuppressive agents are the main causes of DILI in our hospitalized patients,and the ursodeoxycholic acid could improve the efficacy of ba-sic treatment such as glycyrrhizin in patients with DILI.关键词
药物性肝损伤/诱发药物/熊去氧胆酸/中药Key words
Drug-induced liver injury/Common agents/Ursodeoxycholic acid/Traditional Chinese medicine引用本文复制引用
施慧,魏娟,王震凯,王少东,杨妙芳,路又可,刘炯,汪芳裕..住院患者药物性肝损伤病因分析及熊去氧胆酸协同治疗疗效观察[J].实用肝脏病杂志,2015,(1):34-37,4.
