摘要
Abstract
Objective To analyze the clinical features,outcomes,prognosis and related risk factors of cir-rhotic patients complicated with diabetes. Methods Retrospective analysis was conducted in 133 cases of cir-rhotic patients complicated with diabetes and 137 random cases of cirrhotic patients without diabetes from January 2011 to December 2011;the clinical characteristics,biochemical examination,complications,classification of liver function and disease outcome were recorded and compared. Results Average age of cirrhotic patients complicated with diabetes and non-diabetic cirrhotic patients were(55.9±11.0) years and(50.2 ±12.0) years respectively,aver-age hospital stays were(15.6±11.3) days and (12.8±8.4) days,fasting blood glucose were (9.8±5.5) mmol/L and (5.1±2.1) mmol/L,aspartate aminotransferase (AST) were (83.2±98.6) u/L and (65.3±88.8) u/L,albumin (ALB) were (29.1±4.7) g/L and (30.5±5.5) g/L,triglycerides were (1.1±0.9) mmol/L and (0.7±0.4) mmol/L,and serum sodium were (134.3±5.1) mmol/L and(135.8 ± 5.7) mmol/L,respectively (P<0.05 for all). In patients with dia-betes,the numbers of alcoholic causes,Child-Pugh C grade,ascites,spontaneous bacterial peritonitis,hepatic en-cephalopathy and hypertension were significantly higher than those without diabetes (11.3 vs 3.7%,26.3 vs 11.3%, 36.8 vs 29.9%,33.8 vs 22.6%,18.0 vs 9.0% and 21.1 vs 2.9%,respectively,P<0.05 for all);Meanwhile,the mor-tality during hospitalization of patients with diabetes was significantly higher than that of patients without diabetes (18.8 vs 9.5%,P<0.05). The Logistic analysis revealed that advanced age,duration of hospitalization,hyperten-sion,hyperglycemia and triglyceride were the risk factor for diabetes in cirrhotic patients (odds ratio were 1.054, 1.052,16.182,1.503 and 1.503 respectively,P<0.01 for all). Conclusion Compared with cirrhotic patients without diabetes,liver function and prognosis of cirrhotic patients with diabetes was poorer. Diabetes may contribute to the poor prognosis of patients with cirrhosis.关键词
肝硬化/糖尿病/Logistic分析/危险因素/预后Key words
Cirrhosis/Diabetes/Logistic analysis/Risk factor/Prognosis
