实用肝脏病杂志Issue(1)：92-96,5.DOI:10.3969/j.issn.1672-5069.2015.01.027
内质网应激诱导未折叠蛋白反应干预药物作用研究进展
Endoplasmic reticulum stress-induced unfolded protein response in medicine
郭媛媛 1任锋(综述) 2段钟平 2张桓虎(审校)1
作者信息
- 1. 030001 太原市 山西医科大学第二临床医学院肝病科
- 2. 首都医科大学附属北京佑安医院
- 折叠
摘要
Abstract
Endoplasmic reticulum (ER) homeostasis is perturbed by various pathological conditions,and a given new syn-thesized unfolded proteins might accumulate in the ER and result in endoplasmic reticulum stress (ERS). ERS is related to the pathogenesis of the various liver diseases,and some scholars believe that the intervention of ERS will provide new choices for prevention and treatment of liver diseases. This paper will review the unfolded protein response due to ERS,which might be the target for medical intervention for liver diseases.关键词
内质网应激/未折叠蛋白反应/抑制剂/基因治疗Key words
Endoplasmic reticulum stress/Unfolded protein response/Inhibitor/Gene therapy引用本文复制引用
郭媛媛,任锋(综述),段钟平,张桓虎(审校)..内质网应激诱导未折叠蛋白反应干预药物作用研究进展[J].实用肝脏病杂志,2015,(1):92-96,5.
