实用肝脏病杂志Issue(2)：160-163,4.DOI:10.3969/j.issn.1672-5069.2015.02.013
138例药物性肝损伤患者影响预后的因素分析
Prognostic factors in patients with drug-induced liver injuries
摘要
Abstract
Objective To investigate the prognostic factors of drug-induced liver injury(DILI). Methods Sixty-nine patients with DILI were included in this study from July 2008 to July 2014. The factors were as-sessed by Logistic regression analysis. Results The ages of patients with DILI were mainly among 50 to 59 year old. The number of female patients was more than male ones. The most common clinical manifestation in this series was hepatocyte type(78.3%),the second was cholestasis type and the third was mixed type. The pa-tients at different ages had no significant difference in clinical types(P>0.05). The recovered patients accounted for 76.1%,and the unrecovered one was 23.9%. TCM-induced DILI accounted for 43.5% of patients and their prognosis was relatively poor.The prognosis of DILI was not associated with age,gender,and underlying chronic diseases(P>0.05),but significantly associated with the clinical type,history of allergies and immune characteristic clinical manifestation(P<0.05). The total bilirubin,total bile acid and alkaline phosphatase were the independent predictors for prognosis of DILI patients(P<0.05). Conclusion The prognosis of patients with DILI mainly de-pends on the drug category and the individual physical features.关键词
药物性肝损伤/预后/肝功能指标Key words
Drug-induced liver injury/Prognosis/Hepatic function index引用本文复制引用
刘丽娜,赵建学,陆玮婷,陈广梅,陈婉..138例药物性肝损伤患者影响预后的因素分析[J].实用肝脏病杂志,2015,(2):160-163,4.基金项目
江苏省自然科学基金青年基金项目（编号BK20140959）；高等学校博士学科点专项科研基金 （）
