实用肝脏病杂志Issue(2)：205-208,4.DOI:10.3969/j.issn.1672-5069.2015.02.029
隐匿性乙型肝炎病毒感染研究进展
Occult hepatitis B virus infection：Present and future
摘要
Abstract
Occult hepatitis B virus (HBV) infection (OBI) is defined as the status with persistent serum HBsAg negative, but with serum/intrahepatic HBV DNA positive. Due to the differences in prevalence of HBV infection,prevalent viral strains, study samples,as well as sensitivity and specificity of methodology,the available data of OBI prevalence quite varied. The patho-genesis of OBI has not been fully elucidated. It is a complex process involving multiple virological and host factors. OBI can be transmitted through blood transfusion,parturition and liver transplantation to cause de novo infection. Immune dysfunction andap-plication of immunosuppressive agents can lead to OBI reactivation and recurrence of typical serological evidence. The slight but persistent necro-inflammation can promote the progression of liver disease and increase the risk of tumorigenesis. In clinic,more sensitive detection methods are needed for diagnosis of OBI to reduce OBI-related potential threat and help clinicians to take reasonable managements to slow the progression of the disease.关键词
乙型肝炎/隐匿性HBV感染/HBsAg/肝细胞癌Key words
Hepatitis B virus/Occult hepatitis B virus infection/Hepatitis B virus surface antigens/Hepatocellular carcinoma引用本文复制引用
陈建宏,刘妍,李进(综述),徐东平(审校)..隐匿性乙型肝炎病毒感染研究进展[J].实用肝脏病杂志,2015,(2):205-208,4.基金项目
国家自然科学基金项目 （）
