摘要
Abstract
Objective To investigate the clinical effect of adefovir dipivoxil (ADV) combined with Compound Biejia Ruangan tablets in the treatment of patients with chronic hepatitis B (CHB). Methods 80 patients with CHB were randomly divided into control (n=40) and treatment group (n=40). Patients in control group were given ADV, while patients in treatment group were given ADV combined with Compound Biejia Ruangan tablets for 6 months. Clinical symptoms and signs,liver function,hepatic fibrosis indicators,abdominal ultrasonographic indicators such as portal vein diameter, splenic vein diameter as well as thickness of spleen,and serum HBV DNA levels, HBeAg seroconversion after the treatment were recorded. Results At the end of the treatment,ALT,AST,ALB and TBil in patients of control group were(57.84±16.11)U/L,(51.55±18.46)U/L,(33.43±4.76)g/L and(25.74±4.85)μmol/L respectively,and those in patients of treatment group were (38.47±13.43) U/L,(35.74±15.17) U/L, (26.25±4.57) g/L and (15.27±3.36)μmol/L respectively;The HA,LN,PC-Ⅲ and Ⅳ-C in patients of control group were(168.53±86.21)μg/L,(121.45±38.56)μg/L,(131.61±34.49)μg/L and (123.53±31.67)μg/L re-spectively,and those in patients of treatment group were (87.57± 42.53)μg/L,(62.74±21.87)μg/L,(88.74± 28.32)μg/L and(67.63±16.67)μg/L respectively;The portal vein diameters,splenic vein diameters and thickness of spleen in patients of control group were (1.42±0.20) cm,(0.78±0.09) cm and (4.65±0.43) cm respectively,and those in patients of treatment group were(1.31±0.21) cm,(0.74±0.07) cm and (4.24±0.38) cm respectively;Above-mentioned indica tors in treatment group had more remarkable decreased compared with patients in control group (P<0.05);The levels of serum HBV DNA after thetreatment in patients of control group decreased from (6.12 ± 1.66) log10 copies/ml to (3.57 ± 1.21) log10 copies/ml,and in patients of treatment group decreased from (5.93±1.84)log10 copies/ml to (3.43±1.17)log10 copies/ml,showing there was no significant difference in HBV DNA levels after the treatment between the two groups. Conclusion ADV combined with Compound Biejia Ruangan tablets has a satisfactory clinical outcome in patients with CHB.关键词
慢性乙型肝炎/阿德福韦酯/复方鳖甲软肝片/肝纤维化Key words
Chronic hepatitis B/Adefovir dipivoxil/Compound Biejia Ruangan tablets/Hepatic fibrosis
