实用肝脏病杂志2015，Vol.18Issue(3)：321-324,4.DOI:10.3969/j.issn.1672-5069.2015.02.031
血红素加氧酶-1在慢性肝病发病中的作用研究进展
Heme oxygenase-1 in the pathogenesis of chronic liver diseases
摘要
Abstract
Heme oxygenase-1 (HO-1) is a microsomal enzyme and rate-limiting enzyme that catalyzes the degradation of heme into biliverdin,iron atoms and carbon monoxide (CO). It is reported that HO-1 and its breakdown products play vital physiolog-ical roles in anti-inflammation,anti-oxidation and regulation of apoptosis. Its roles in the pathogenesis of liver diseases in recent years have gradually be elucidated,and it is promising for an option in the treatment of chronic liver disease in the future. In this paper,we will review the research progress about HO-1 in the viral hepatitis,liver fibrosis,hepatocellular carcinoma and hep-atic ischemia-reperfusion injury.关键词
病毒性肝炎/肝细胞癌/缺血再灌注损伤/血红素加氧酶-1Key words
Viral hepatitis/Hepatocellular carcinoma/Ischemia-reperfusion injury/Heme oxygenase-1引用本文复制引用
嵇小琴..血红素加氧酶-1在慢性肝病发病中的作用研究进展[J].实用肝脏病杂志,2015,18(3):321-324,4.基金项目
安徽省科技厅自然科学基金 (编号:1208085QH147) （编号:1208085QH147）
安徽省教育厅自然基金(编号:KJ2012A174) （编号:KJ2012A174）
