实用医学杂志Issue(7)：1080-1083,4.DOI:10.3969/j.issn.1006-5725.2014.07.022
TIAM2功能性基因突变对冠心病患者氯吡格雷抗血小板治疗后出血事件的影响
TIAM2 functional gene mutation has no effect of on bleeding events after clopidogrel antiplatelet therapy in patients with coronary heart disease
摘要
Abstract
Objective To explore the correlation of the TIAM2 functional gene mutations with the bleeding events in patients with coronary heart disease who undergone PCI and postoperative taken anti-platelet drug clopi-dogrel. Methods One hundred and twenty Chinese Han patients who had undergone PCI and postoperative taken anti-platelet drug clopidogrel were orderly enrolled from Guangdong General Hospital. Followed for 6 months after PCI, PCR sequencing was applied to test TIAM2 promoter region genotyping assay. Results After follow-up six months , 113 cases were remained lost of 7 cases , , including 19 cases with bleeding and 94 cases without bleed-ing; Bleeding risk in patients with diabetes mellitus (OR=3.115) or taking statins (OR=11.539), may be high, but there was no significant difference (P > 0.05); TIAM2 promoter region had three variants (c.3168+3116C>T, c.3168+3261A>G,c.3168+3596A>C), including wild-type, heterozygous, and homozygous. The probability of pa-tients with bleeding were 36.84%, 52.63%and 10.53%, and there is a certain chain of state , but the genotype was not significantly correlated with bleeding events of clopidogrel antiplatelet therapy (P>0.05). Conclusion Clopi-dogrel antiplatelet therapy bleeding events were not significantly correlated with TIAM2 functional gene mutation.关键词
冠心病/TIAM2基因/氯吡格雷/出血事件Key words
Coronary disease/TIAM2 gene/Clopidogrel/Bleeding events引用本文复制引用
李新新,钟诗龙,李园,韦素惠,张梦珍,祁周措,陈纪言,劳海燕..TIAM2功能性基因突变对冠心病患者氯吡格雷抗血小板治疗后出血事件的影响[J].实用医学杂志,2014,(7):1080-1083,4.基金项目
国家自然科学基金项目（编号81373486）；广东省科技计划项目 （）
