实用医学杂志Issue(9)：1391-1394,4.DOI:10.3969/j.issn.1006-5725.2014.09.015
p33ING1b和p53在银屑病和基底细胞癌中的表达及临床意义
Expressions and clinical significance of p33ING1b and p53 in psoriasis and basal cell carcinoma
摘要
Abstract
Objective To discuss the expressions and clinical significance of p53 and p33ING1b in human psoriasis and basal cell carcinoma (BCC). Methods Immunohistochemistry EnVision technique was used to detect the expressions of p53 and p33ING1b in samples of 36 psoriasis vulgaris, 28 BCC and 14 normal skins. Results The expression of p53 increased while p33ING1b had a degressive expression in the control group, the psoriasis group and the BCC group. It was found significant statistical difference between the two groups (all P < 0.05). Prominent positive correlation between p53 and p33ING1b were found in both psoriasis group and BCC group (all P<0.05). Conclusions p53 coacts with p33ING1b at local lesions of abnormal proliferative diseases . It′s one of the most prominent mechanisms contributing to deviant cell proliferation.关键词
p53/p33ING1b/银屑病/基底细胞癌/ING1Key words
p53/p33ING1b/Psoriasis/Basal cell carcinoma/Inhibitor of growth 1 gene引用本文复制引用
贺琪,岳青,皮先明,石全,陈宏翔,李家文..p33ING1b和p53在银屑病和基底细胞癌中的表达及临床意义[J].实用医学杂志,2014,(9):1391-1394,4.基金项目
国家自然科学基金资助项目（编号30972654，81271765，81171495）；湖北省自然科学基金资助项目 （）
