实用医学杂志Issue(10)：1537-1540,4.DOI:10.3969/j.issn.1006-5725.2014.10.007
芦荟减阻剂对烧伤休克大鼠微循环的影响
Effects of Drag-reducing polymer derived from Aloe vera on microcirculation in burn rats
摘要
Abstract
Objective To investigate the effects of drag-reducing polymers on microcirculation in 40%total body surface area burn-injured rats. Methods SD rats were randomized into control group, drag-reducing polymer (DRPs) group and normal saline (NS) group (5 minutes after scald, drag-reducing polymer or saline was injected for fluid resuscitation). Wet dry weigh ratio of lung, histopathologic changes and arterial blood gas at 24 hour were respectively measured by wet dry weigh ratio method, hematoxylin-eosin (HE) staining and arterial blood gas analysis. The velocity of flow of red cell in oblique ridge and the survival time of burn-injured rats were observed. Results Compared with control group, rats in NS group exhibit significant lung injury characterized by a high W/D (P < 0.01), accumulation of a large number of neutrophils in HE stain, low partial pressure of oxygen (PO2) and high lactate (Lac) (P<0.05 or P<0.01) in arterial blood. Compared with the NS group, DRPs treatment rats exhibit significantly reduced lung injury characterized by W/D reducing (P < 0.05), the reduction of neutrophil infiltration, increased PO2, decreased Lac (P<0.05, P<0.01). In addition, DRPs treatment obviously increases the burn-induced low velocity of flow of red cell in oblique ridge (P<0.01). Moreover, the survival time of burned rats can be improved by DRPs treatment (P < 0.05). Conclusion DRPs ameliorates burn-induced acute lung injury, the mechanism may be through improving the burn-induced microcirculation disorders.关键词
肺损伤/芦荟减阻剂/烧伤休克/微循环Key words
Aloe vera/Drag-reducing polymers/Acute lung injury/Burn Shock/Microcirculation引用本文复制引用
张俊莉,蔡淑敏,李涛,曾振华,高友光,陈仲清..芦荟减阻剂对烧伤休克大鼠微循环的影响[J].实用医学杂志,2014,(10):1537-1540,4.基金项目
广东省科技计划项目 （）
