实用医学杂志Issue(10)：1626-1628,1629,4.DOI:10.3969/j.issn.1006-5725.2014.10.037
羟乙基淀粉对急性胰腺炎患者肾功能和凝血功能的影响
The effects of hydroxyethyl starch on renal function and blood coagulation of patients with acute pancreatitis
摘要
Abstract
Objective To evaluate the effects of hydroxyethyl starch (HES) on the renal function and blood coagulation of patients with acute pancreatitis (AP). Methods 151 patients with acute pancreatits were divided into treatment group (treated with HES, n=62) and control group (treated with crystalloid solutions, n =89). The two groups were compared by retrospective analysis of the indices such as serum creatinine (Scr), blood urea nitrogen (Bun), platelet count(Plt), prothrombin time activity (PTA), international normalized ratio (INR), activated partial thromboplastin time (APTT) and fibrinogen (FIB) before and after treatment. Results Before hospitalization, there were insignificant differences in respect of Scr and Bun in the two groups respectively. But at discharge, Scr and Bun in the treatment group were significantly increased (P<0.05), while Bun was significantly decreased 24 h right after infusion of crystalloid solutions in the control group (P<0.05). There were no differences between the two groups in terms of Scr and Bun. As for indices of coagulation, APTT in the treatment group was significantly increased after infusion of HES (P<0.05). The hospital stay in the treatment group was longer than the control group (P < 0.05). Conclusions HES may adversely affect renal function and intrinsic pathway of blood coagulation of patients with AP. Renal function and blood coagulation should be monitored when using HES.关键词
急性胰腺炎/羟乙基淀粉/肾功能/凝血功能Key words
Acute pancreatitis/Hydroxyethyl starch/Renal function/Blood coagulation引用本文复制引用
李邦一,张玫,朱鸿明,赵丹丹,杨燕..羟乙基淀粉对急性胰腺炎患者肾功能和凝血功能的影响[J].实用医学杂志,2014,(10):1626-1628,1629,4.基金项目
北京市教育委员会科技计划面上项目 （）
