实用医学杂志Issue(11)：1709-1711,3.DOI:10.3969/j.issn.1006-5725.2014.11.009
姜黄素对糖尿病痛性周围神经病变大鼠脊髓炎症因子的影响
Effect of curcumin on spinal inflammatory factor in rats with diabetic neuropathy
摘要
Abstract
Objective To evaluate the effect of curcumin on spinal inflammatory factor in rats with diabetic neuropathy. Methods Diabetic neuropathy was induced by intraperitoneal injection with 1% STZ (60 mg/kg) in sprague-dawley rats. These diabetic rats were randomly allocated to diabetic group (D group, n=10) and curcumin group ( C group , n = 10 ) . Another 10 age-matched normal rats served as controlled group ( N group , n = 10 ) . 28 days after STZ injection, the rats in C group received daily intragastric administration of curcumin (200 mg/kg) whereas those in D group received the same volume of normal saline for 2 weeks. Caudal vein blood glucose levels at T1( before STZ injection)and at T2-T8(2、7、14、21、28、35、42 days after STZ injection)from all rats were detected. Responses to the mechanical stimulus were measured with von Frey filament, and paw withdraw threshold (PWT) was recorded at T1 and at T3 to T8. At T8,the rats were killed and lumbar segments of spinal cord were removed to detect TNF-αand IL-6 content. Results Compared to N group, rats in both C and D group showed hyperglycemia at T2 to T8 (P<0.05) and lower PWT at T4~ 8 (P < 0.01). Compared to D group, C group showed higher PWT at T7,8(P<0.05). Both D and C group showed higher levels of blood sugar at T2 ~ 8 than that at T1 (P < 0.05). C group showed higher PWT at T7,8 than that at T6(P<0.05). Compared to N group,spinal TNF-αand IL-6 content increased in both D and C groups (P<0.05). Compared to D group, C group had reduction of TNF-αand IL-6 concentration (P < 0.05). Conclusion Curcumin can attenuate diabetic neuropathic pain on rats probably by reducing inflammatory factor in spinal cord.关键词
糖尿病周围神经病变/姜黄素/脊髓/炎症因子Key words
Curcumin/Diabetic peripheral neuropathy/Spinal cord/Inflammatory factor引用本文复制引用
张文璇,赵伟成,廖美娟,杨承祥..姜黄素对糖尿病痛性周围神经病变大鼠脊髓炎症因子的影响[J].实用医学杂志,2014,(11):1709-1711,3.基金项目
广东省自然科学基金项目 （）
