实用医学杂志Issue(11)：1722-1724,3.DOI:10.3969/j.issn.1006-5725.2014.11.013
MTHFR基因单核苷酸多态性与中国南方汉族阿尔茨海默病的相关性分析
Correlation research between single nucleotide polymorphism of methylenetetrahydrofolate reductase and Alzheimer′s disease in South China Han people
摘要
Abstract
Objective To investigate the relationship between single nucleotide polymorphism (677C→T) of methylenetetrahydrofolate reductase and Alzheimer′s disease(AD) in south China Han people. Methods By applying polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP), MTHFR 677C→T mutation was detected in 45 AD patients and 48 healthy controls. Results The frequency of MTHFR 677C→T mutation of patients showed no significant difference to that of healthy controls (P > 0.05). There is no statistic significance between AD group and controls in C, T gene frequency(P>0.05). But T gene frequency is higher in AD group than in control group. Conclusion MTHFR C 677T is not the pathogenic factor for AD, but could have some effects on AD.关键词
亚甲基四氢叶酸还原酶/单核苷酸多态性/阿尔茨海默病Key words
Methylenetetrahyfrofolate reductase/Single nucleotide polymorphism/Alzheimer′s disease引用本文复制引用
赵娟,周正艳,蔡超群,禹华旭,周毅..MTHFR基因单核苷酸多态性与中国南方汉族阿尔茨海默病的相关性分析[J].实用医学杂志,2014,(11):1722-1724,3.基金项目
湖南省教育厅科研项目 （）
