实用医学杂志Issue(12)：1902-1905,4.DOI:10.3969/j.issn.1006-5725.2014.12.014
上皮性卵巢癌组织中MEG3基因异常甲基化状态及其临床意义
Methylation state of MEG3 gene in epithelial ovarian cancer and its clinical significanc research
摘要
Abstract
Objective To study the relationship between the methylation status of CPG islands in MEG3 gene promoter region of epithelial ovarian cancer and its clinical and pathological features. Methods The promoter methylation status was evaluated by MSP (methylation-specific polymerase chain reaction ) in 47 cases of ovarian cancer tissue and 15 cases of normal control. Results The methylation ratio (42.6%) of the MEG3 genes in the ovarian cancer was statistically significantly higher (P = 0.035 ) than that (13.3%) in the normal control. The methyation rate of the group with an age > 60 years old was slightly higher than that of the group with an age≤60 years old, without statistically significant (P > 0.05), so was observed in ovarian cancers of stage Ⅰ andⅡ than that in stage Ⅲ and Ⅳ. There were also no significant differences in MEG3 gene methylation positive rate neither in different pathological grading nor in various ovarian cancer tissues (P > 0.05). Conclusion Abnormal methylation in MEG3 gene may be associated with epithelial ovarian cancer , but no relation to its clinical pathology.关键词
卵巢肿瘤/MEG3/甲基化Key words
Ovarian neoplasms/MEG3/Methylation引用本文复制引用
赵琴,李剑琦,周艳清,谭琳玉,李娟,生秀杰..上皮性卵巢癌组织中MEG3基因异常甲基化状态及其临床意义[J].实用医学杂志,2014,(12):1902-1905,4.基金项目
广州市科技计划资助项目 （）
