实用医学杂志Issue(12)：1906-1909,4.DOI:10.3969/j.issn.1006-5725.2014.12.015
小细胞肺癌患者循环肿瘤细胞检测的临床意义
Clinical significance of circulating tumor cells detection in small cell lung cancer patients
摘要
Abstract
Objective To investigate the clinical significance of circulating tumor cells (CTCs) in pa-tients with small-cell lung cancer patients (SCLC). Methods 42 SCLC patients, 10 patients with benign lung disease(hospitalized from June 2012 to June 2013), and 10 healthy volunteers from the First Affiliated Hospital of Shihezi University Medical College were studied and their clinical information was collected. Negative immuno-magnetic separation method and immunocytochemistry method were applied to collect the Pan-CK +/CD45 - of CTCs, in order to analyze the relationship between CTCs and clinical manifestation. Results CTCs were found in 32 cases of SCLC group, with a positive rate of 76.19%. CTCs was not found in peripheral blood in control group. Difference in the two groups is significant (P = 0.000). The presence of CTCs was correlated positively with the patients′ PS score , clinical stage , M stage , the number of metastatic sites , NSE value and LDH value (P < 0.05). Conclusion The CTCs number is correlated with patients′ PS score, clinical stage, M stage, the number of metastatic sites, NSE value and LDH value, respectively. CTCs detection is useful for more accurate risk assessment of patients.关键词
癌,非小细胞肺/循环肿瘤细胞/临床特征/NSE/LDHKey words
Small-cell lung cancer/Circulating tumor cells/Clinical characteristics/NSE/LDH引用本文复制引用
刘春花,杨政,李晶,巩平..小细胞肺癌患者循环肿瘤细胞检测的临床意义[J].实用医学杂志,2014,(12):1906-1909,4.基金项目
新疆生产建设兵团科技计划专项基金（编号2012BA042）；世界卫生组织国际临床试验注册项目 （）
