实用医学杂志Issue(12)：1979-1981,3.DOI:10.3969/j.issn.1006-5725.2014.12.041
丙泊酚靶控输注时舒芬太尼抑制视频喉镜插管的效应室浓度
Effect-site concentration of sufentanil blunting responses to tracheal intubation with video laryngoscope during propofol TCI
摘要
Abstract
Objective To deter mine the effect-site concentration of sufentanil blunting responses to tracheal intubation with video laryngoscope during propofol target controlled infusion (TCI). Methods Twenty-three patients undergoing selective surgery under general anesthesia were enrolled in this study. Induction of anesthesia was initiated by TCI sufentanil at the target effect-site concentration 3 min later , TCI of propofol began at the target plasma concentration of 3 μg/mL. Cisatracurium 0.15 mg/kg was ad ministrated for video laryngoscope tracheal intubation after loss of consciousness. The target concentration of sufentanil for consecutive patients was deter mined using the modified Dixon′s up-and-down method by the intubation response of the previous patient , in an increment or decrement of 0.05 ng/mL. The initial concentration was set at 0.4 ng/mL. Results The EC50 of Sufentanil was 0.32 ng/mL with 95%confidence interval of 0.29~0.35 ng/mL; the EC95 was 0.38 ng/mL with 95%confidence interval 0.35-0.55 ng/mL during video laryngoscope tracheal intubation. Conclusion The EC50 and EC95of sufentanil blunting responses to tracheal intubation with video laryngoscope are 0.32 ng/mL and 0.38 ng/mL during propofol TCI.关键词
舒芬太尼/效应室浓度/视频喉镜Key words
Sufentanil/Effect-site concentration/Video laryngoscope引用本文复制引用
邵伟栋,胡渤,张兴安,钱传沐,徐波..丙泊酚靶控输注时舒芬太尼抑制视频喉镜插管的效应室浓度[J].实用医学杂志,2014,(12):1979-1981,3.基金项目
全军医学科技青年培育项目 （）
