实用医学杂志Issue(14)：2193-2195,2196,4.DOI:10.3969/j.issn.1006-5725.2014.14.003
紫杉醇长循环热敏脂质体对Lewis肺癌荷瘤鼠的药效学研究
Pharmacodynamics of paclitaxel long-circulating thermo sensitive liposomes in Lewis tumor-bearing mice
摘要
Abstract
Objective To investigate the tumor inhibition effect of paclitaxel long-circulating thermo sensitive liposomes (PLTL) in mice bearing Lewis lung carcinoma cells. Methods A tumor-bearing mouse model was established, and the mice were randomly divided into five groups: control, heating, paclitaxel (PTX), paclitaxel thermo sensitive liposomes (PTL), and PLTL groups. The living status was observed in the mice. The volume and weight of the tumor were measured. The morphological changes in the tumor cells were observed f by HE staining and apoptosis of the tumor cells was determined by flow cytometry. Results The inhibition rate of tumor in PTX, PTL and PLTL groups was 48.87%, 57.22%and 78.87%, respectively. The apoptotic rate of tumor cell in PTX, PTL and PLTL groups was (42.7 ± 3 .8)%, (54.6 ± 2.9)%and (69.7 ± 5.0)%, respectively. Conclusions PLTL, as compared with PTX and PTL, has an evident thermo sensitive feature and increases the anticancer effect of paclitaxel remarkably in combination with local hyperthermia.关键词
紫杉醇/长循环热敏脂质体/热敏脂质体/热疗Key words
Paclitaxel/Long-circulating thermo sensitive liposomes/Thermo sensitivity liposomes/Hyperthermia引用本文复制引用
李美波,顾生玖,赵文鹏,朱开梅..紫杉醇长循环热敏脂质体对Lewis肺癌荷瘤鼠的药效学研究[J].实用医学杂志,2014,(14):2193-2195,2196,4.基金项目
广西科技攻关项目（编号桂科能129825-21，桂科合14123001-22）；广西教育厅项目（编号201202ZD065，2013lX080）；桂林市科技攻关项目 （）
