实用医学杂志Issue(14)：2225-2227,3.DOI:10.3969/j.issn.1006-5725.2014.14.013
IL-17在口腔扁平苔藓病损中的表达及其对趋化因子CCL20表达的促进作用
IL-17 expression in lesions of oral lichen planus and its auxo-action for chemokine CCL20 expression
谢三祥 1丰琳 2朱声荣 1丁蕾1
作者信息
- 1. 430030 武汉市，华中科技大学同济医学院附属同济医院口腔医学中心
- 2. 438000 黄冈市，湖北省黄冈市妇幼保健院
- 折叠
摘要
Abstract
Objective To investigate the mechanism of IL-17, the signature cytokine produced by Th17 cells, in OLP lesion. Methods 24 patients with reticular OLP, 19 patients with atrophic-erosive OLP and 13 healthy volunteers were enrolled in this study . Real-time quantitative PCR ( real-time qPCR ) was performed to analyze the expressions of the production of IL-17 and CCL20 mRNA. Results The expressions of IL-17 mRNA in reticular OLP and atrophic-erosive OLP were significant higher than that in healthy oral mucosa (P = 0.0095, P <0.0001, respectively), meanwhile, remarkable increased IL-17 expression in atrophic-erosive OLP group was found compared with reticular OLP group (P = 0.0012). Additionally, the expressions of CCL20 mRNA in reticular OLP and atrophic-erosive OLP were significant higher than that in control group (P=0.0357, P<0.0001, respectively), meanwhile, CCL20 expression in atrophic-erosive OLP was higher than that in reticular OLP. The expressions of CCL20 mRNA rises with the increased expression of IL-17, and were positive correlated with IL-17 expressions in OLP lesions (P=0.003). Conclusions IL-17 production can induce chemokine CCL20 expression in OLP lesion. The signal pathway may promote the migration and infiltration of inflammatory cells in OLP lesions.关键词
口腔扁平苔藓/CCL20/IL-17/Th17Key words
Oral lichen planus/CCL20/IL-17/Th17引用本文复制引用
谢三祥,丰琳,朱声荣,丁蕾..IL-17在口腔扁平苔藓病损中的表达及其对趋化因子CCL20表达的促进作用[J].实用医学杂志,2014,(14):2225-2227,3.
