实用医学杂志Issue(14)：2300-2301,2.DOI:10.3969/j.issn.1006-5725.2014.14.042
右美托咪定对老年患者全麻术后认知功能及炎症因子的影响
Clinical analysis of effect of Dexmedetomidine on postoperative cognitive function and preoperative inflammation in the elderly patients undergoing general anesthesia
摘要
Abstract
Objective To study the effect of dexmedetomidine (DEX) on postoperative cognitive function and preoperative inflammation in the elderly patients undergoing general anesthesia. Methods 70 elderly patients undergoing general anesthesia operation were chosen and divided into observation group and control group randomly. DEX and physiological saline were applied in observation group on the basis of routine general anesthesia. The cognitive function of patients in both groups were tested by mini-mental state examination (MMSE) and the incidence rate of cognitive dysfunction (POCD) were measured at 1 day before surgery, 1 day, 3 days, 5 days, and 7 days after surgery. The level of interleukin-6 (IL-6) and tumor necrosis factor-α(TNF-α) were tested before anesthesia, during skin incision, rightly after operation and 1h after operation. Results MMSE scores were significantly higher and the incident rates of POCD were lower in observation group than those in control group at 1 day and 3 days after surgery (P<0.05). The levels of IL-6 and TNF-αincreased obviously during skin incision and postoperative period, and they were significantly lower in observation group (P<0.05). The levels of IL-6 and TNF-αdecreased to the levels before anesthesia in observation group, and were still much higher in control group than that of preanesthesia (P < 0.05). Conclusions DEX infusion intraoperatively may effectively decrease the incidence of early POCD, whose mechanism could be reducing inflammation response.关键词
右美托咪定/老年/认知功能/TNF-α/IL-6Key words
Dexmedetomidine/Senium/Cognitive function/TNF-α/IL-6引用本文复制引用
孟海兵,来伟,帅君,丁国友..右美托咪定对老年患者全麻术后认知功能及炎症因子的影响[J].实用医学杂志,2014,(14):2300-2301,2.基金项目
江西省卫生厅科技计划 （）
