实用医学杂志Issue(15)：2373-2376,4.DOI:10.3969/j.issn.1006-5725.2014.15.007
特拉唑嗪对大鼠动脉粥样硬化斑块中基质金属蛋白酶9与单核细胞趋化因子-1表达的影响
Effect of terazosin on expressions of matrix metalloproteinase-9 and monocyte chemotactic protein 1 in a rat model of atherosclerosis
摘要
Abstract
Objective To investigate the effects of terazosin on expressions of matrix metalloproteinase-9 (MMP-9) and monocyte chemotactic protein 1 (MCP-1) in a rat model of atherosclerosis and to explore the mecha-nism for reducing atherosclerosis by terazosin. Methods Normal rats were fed with high lipid feedstuff to set up a rat model of atherosclerosis. Blood lipid indexes were measured and the expressions of MMP-9 and MCP-1 in aorta were detected and further quantified by immunohistochemistry after 12-week high lipid feedstuff. Results The plasma concentration of TG, TC, LDL in the terazosin group were significantly lower than those in the high cholesterol-diet group (P<0.01). The expressions of MMP-9 and MCP-1 in the high cholesterol-diet group and in the terazosin group were significantly higher than those in the normal-diet group (P < 0.01), but expressions of MMP-9 and MCP-1 in the terazosin group were significantly lower than those in the high cholesterol-diet group (P<0.01). Conclusion Terazosin can lower the concentration of TC, LDL but increase the HDL concentration. The anti-atherosclerotic mechanism of terazosin is associated with the decrease of the expressions of MMP-9 and MCP-1 and plasma lipoprotein.关键词
动脉粥样硬化/特拉唑嗪/基质金属蛋白酶9/单核细胞趋化因子-1Key words
Atherosclerosis/Terazosin/Matrix metalloproteinase-9/Monocyte chemotactic protein 1引用本文复制引用
陈玲,周炜,陈曼华..特拉唑嗪对大鼠动脉粥样硬化斑块中基质金属蛋白酶9与单核细胞趋化因子-1表达的影响[J].实用医学杂志,2014,(15):2373-2376,4.基金项目
武汉市科技局关键技术攻关项目 （）
