实用医学杂志Issue(16)：2532-2534,3.DOI:10.3969/j.issn.1006-5725.2014.16.003
高张盐水后处理对大鼠局灶性脑缺血再灌注损伤TNF-α、IL-1β、S-100β的影响
Effects of hypertonic saline on TNF-α、IL-1β、S-100β following focal cerebral ischemia-reperfusion injury in rats
摘要
Abstract
Objective To investigate the effect of hypertonic saline on TNF-а, IL-1β, S-100β level following focal cerebral ischemia-reperfusion injury in rats and explore the mechanisms involved. Methods Ninety rats were randomized equally into 4 groups,namely the pseudo-operated group (A group),untreated IR injury group (B group),C group (4.2% hypertonic saline) and D group (7.5% hypertonic saline). Cerebral ischemia was induced by middle cerebral artery occlusion for 2 h followed by administration of the corresponding treatments in group C and D. After 22 h of reperfusion , TNF-а, IL-1β, S-100βexpression in the ischemic brain tissue were measured by enzyme-linked immunosorbent assay (ELISA). Results After hypcrtonic saline treatment, the two saline-treated groups showed significant reduction in TNF-а、IL-1β、S-100β levels , but were still higher than pseudo-operated group(A group). Compared with B group, significant difference can be seen among C and D group. Conclusion Hypcrtonic saline can reduce cerebral TNF-а、IL-1β、S-100βlevel of isehemia-reperfusion injury.关键词
脑缺血再灌注损伤/高张盐水/TNF-α/IL-1β/S-100βKey words
Isehemia-reperfusion/Hypertonic saline/TNF-α/IL-1β/S-100β引用本文复制引用
赖永东,金文香,何荣芝..高张盐水后处理对大鼠局灶性脑缺血再灌注损伤TNF-α、IL-1β、S-100β的影响[J].实用医学杂志,2014,(16):2532-2534,3.基金项目
广东省卫生厅项目 （）
