实用医学杂志Issue(17)：2706-2708,3.DOI:10.3969/j.issn.1006-5725.2014.17.004
PDK1缺失导致血管内皮细胞连接异常
Abnormal vascular endothelial cell junctions caused by PDK1 deficiency
摘要
Abstract
Objective To reveal the role of PDK1 in vascular endothelial cells. Methods PDK1 was knocked out in endothelial cells by recombinase-mediated Cre to observe it′s effects on vascular endothelial cells. Results Abnormality of vascular development in rats could be found as a result of endothelial PDK1 deletion. Meanwhile, vascular leakage and bleeding phenotype were observed, and tissue analysis showed vascular endothelial cells abnormalities. Conclusions PDK1 plays an important role in the functioning and integrity of vascular endothelial cells, which made tentative explanation for PDK1-Akt signal path and laid basis for further research.关键词
PDK1/血管内皮细胞/细胞连接/基因敲除Key words
PDK1/Vascular endothelial cells/Cell connection/Knockout引用本文复制引用
冯秋婷,钱晓军,徐欣,金艳,杨承健..PDK1缺失导致血管内皮细胞连接异常[J].实用医学杂志,2014,(17):2706-2708,3.基金项目
国家自然科学基金青年项目（编号81200168）；南京医科大学重点项目 （）
