实用医学杂志Issue(17)：2715-2717,2718,4.DOI:10.3969/j.issn.1006-5725.2014.17.007
别嘌呤醇对海人酸致颞叶癫痫大鼠的保护作用
Protective effect of allopurinol in kainic acid-induced epileptic rats
摘要
Abstract
Objective To investigate the protective effect of allopurinol in kainic acid-induced epileptic rats and to explore new ideas and methods for the clinical treatment of epilepsy. Methods 120 Wistar rats were randomly divided into sham group, KA epilepsy group and allopurinol groups. Six rats of each group were randomly selected and were given electrodes into their left frontal and hippocampal regions. After injection, behavior changes were observed in all rates without electrodes. 24 h later, MDA level and SOD enzymatic activity of the left hippocampi were measured. One week later, the EEGs were recorded in rates with electrode, as well as total time of seizures /30 min and numbers of seizures / 30 min. Results Compared with the KA model group, latency period of the epilepsy in the allopurinol group was longer (P < 0.05) and the extent was lighter (P < 0.05); the MDA level was significantly lower (P < 0.01), the SOD enzymatic activity was significantly higher (P < 0.01). The total time of seizures / 30min and numbers of seizures / 30 min in allopurinol group reduced significantly (P < 0.01). Conclusion Allopurinol has potential antiepileptic and antioxidative activities in kainic acid-induced epileptic rats.关键词
癫痫/别嘌呤醇/海人酸/氧化应激Key words
Epilepsy/Allopurinol/Kainic acid/Oxidative stress引用本文复制引用
杨永辉,王新军,谢井伟,武跃辉,王振..别嘌呤醇对海人酸致颞叶癫痫大鼠的保护作用[J].实用医学杂志,2014,(17):2715-2717,2718,4.基金项目
河南省科技攻关资助项目（编号092102310090）；郑州市科技领军人才资助项目 （）
