实用医学杂志Issue(17)：2734-2736,3.DOI:10.3969/j.issn.1006-5725.2014.17.013
乳腺浸润癌组织中骨桥蛋白、环氧化酶-2和细胞周期素 D1的表达及其意义
Expressions of OPN, COX-2 and CyclinD1 in breast infiltrating carcinoma and their relationship with clinicopathological features
摘要
Abstract
Objective To observe the expressions of OPN, COX-2 and CyclinD1 in breast infiltrating carcinoma and evaluate their relationships with clinic pathological features. Methods Expression of the above three indexes were detected from 70 breast cancinoma patients by immunohistochemistry. The relationships among them and clinicopathological features were analyzed. Results The positive expression rates of OPN were 78.8% in cases (≤45 years old) and 73.0% in cases (> 45 years old); the positive expression rates were 79.3%(tumor diameter ≤ 3 cm) and 73.2% (tumor diameter > 3 cm); the positive expression rates were 77.8%, 73.8% and 78.9% in cases ofⅠgrade, Ⅱgrade and Ⅲ respectively, the positive rates had no statistical significances(P > 0.05). The expression rates of OPN in cases of breast infiltrating carcinoma without and with axillary node metastasis were 62.5% and 93.3%, in cases at stage Ⅰ~Ⅱ and Ⅲ ~Ⅳ were, 68.0% and 95.0% respectively, the positive rates had statistical significances(P < 0.05). The expression of OPN was negatively correlated with ER and PR while positively correlated with CerbB2, COX-2 and CyclinD1. Conclusions OPN plays an important role in the invasion and metastasis of breast carcinoma coordinated with COX-2 and CyclinD1.关键词
乳腺肿瘤/骨桥蛋白/环氧化酶-2/细胞周期素 D1Key words
Breast neoplasms/OPN/COX-2/CyclinD1引用本文复制引用
郝华,徐芬,邬黎青,李里香,曾磊,张昕昕,龚丹,杨宇晴..乳腺浸润癌组织中骨桥蛋白、环氧化酶-2和细胞周期素 D1的表达及其意义[J].实用医学杂志,2014,(17):2734-2736,3.基金项目
国家青年科学基金项目（编号81301741）；江西省青年科学基金项目（编号20122BAB215007）；江西省自然科学基金项目（编号20132BAB205041）；江西省教育厅青年基金项目 （）
