实用医学杂志Issue(18)：2876-2879,4.DOI:10.3969/j.issn.1006-5725.2014.18.003
TRPV1与μ-阿片受体在胃投射脊髓背根神经节中的共存表达及其临床意义
The coexistence expression of TRPV1 and μ-opoid receptor in spinal dorsal root ganglion projected to stomach and its clinical significance
摘要
Abstract
Objective To observe the coexistence expression of TRPV1 and μ-opoid receptorin spinal dorsal root ganglion (DRG) projected to stomach , and to investigate the relationship between TRPV1 andμ-opoid receptorand its clinical significance in rats with acute gastric mucosal lesion induced by water immersion and restraint stress. Methods FortyWistar rats were randomly assigned to 3 groups, including normal control group(group NC, n = 10), WIRS group (group WIRS, n = 20), and sufentanil pretreatment group (group SP, n = 10). A rat model of gsatric mucosal lesion was induced by WIRS. 6 hours after WIRS treatment, gastric tissues were excised and microscopically observed; ulcer index (GI) was noted. The coexistence expression of TRPV1 and μ-opioid receptor in DRG neurons was detected by immunofluorescence assay, and the levels of CGRP was measured by ELASA. Results As compared withgroup WIRS, the degree of gastric injury was obviously relieved in group SF. Coexistence of TRPV1 and μ-opioid receptor was detected in thoracic DRG neurons projected to stomach; the CGRP level was higher in group WIRS than in group NC. ConclusionsTRPV1 isinvolved in protection of acute gastric mucosal lesion. Activation of μ-opioid receptor can induce TRPV1 to release CGRP, resulting in protection of gastric mucosa.关键词
μ-阿片受体/TRPV1/CGRP,舒芬太尼/急性胃黏膜损伤Key words
μ-opioid receptor/TRPV1/CGRP/Sufentanil/Acut gastric mucosal lesion引用本文复制引用
蒋群,屠伟峰,徐少群,赵高峰,郄文斌,李国才..TRPV1与μ-阿片受体在胃投射脊髓背根神经节中的共存表达及其临床意义[J].实用医学杂志,2014,(18):2876-2879,4.基金项目
国家自然科学基金（编号81272141）；广东省自然科学基金（编号 S2011010003373）；江苏省高校重点实验室开放课题 （）
