实用医学杂志Issue(19)：3070-3072,3.DOI:10.3969/j.issn.1006-5725.2014.19.012
慢性髓系白血病SOX17基因表达及甲基化的临床研究
Clinical study on expression and methylation of SOX17 gene in chronic myeloid leukemia
摘要
Abstract
Objective To investigate the expression level and promoter methylation of SOX17 gene and the clinical correlations in Chinese patients with chronic myeloid leukemia ( CML ) . Methods The levels of SOX17 expression and methylation were detected by RQ-PCR and RQ-MSP. Results SOX17 expression level was significantly lower in CML compared with 30 controls (P=0.001). The area under the receiver operating characteristic (ROC) curve (AUC) was 0.748 to differentiate CML from control (P=0.001). There was a trend of correlation between SOX17 expression and bcr/abl transcript (r = 0.439,P = 0.068) in CML patients. Hypermethylation of SOX17 promoter was detected in 3 (4%) CML patients, however, there was no difference as compared with 32 controls. In our study, SOX17 hypermethylation was not corrected with its expression. Conclusion Decreased SOX17 expression is a common molecular event in CML and may be considered as an available biomarker to diagnose CML. Dysregulated SOX17 is not caused by promoter hypermethylation in CML.关键词
慢性髓系白血病/SOX17/低表达/甲基化Key words
Chronic myeloid leukemia/SOX17/Low expression/Hypermethylation引用本文复制引用
唐春艳,肖高飞,杨磊,钱军,安翠,姚冬明,刘清,郭竑,闻向梅,林江,马吉春,张铭..慢性髓系白血病SOX17基因表达及甲基化的临床研究[J].实用医学杂志,2014,(19):3070-3072,3.基金项目
国家自然科学基金资助项目（编号81270630，81172592）；江苏省科技厅临床医学科技专项课题（编号BL2012056）；江苏省“333工程”项目（编号BRA2011085， BRA2013136）；镇江市医学重点人才、镇江市社会发展项目（编号SH2013042，SH2013082）；江苏大学临床医学科技发展基金资助项目 （）
