实用医学杂志Issue(19)：3079-3081,3.DOI:10.3969/j.issn.1006-5725.2014.19.015
轻度认知障碍患者脑脊液中β-淀粉样蛋白42及磷酸化Tau蛋白的水平检测及意义
Significance and detection of Aβ42 and P-tau levels in CSF of patients with mild cognitive impairment
摘要
Abstract
Objective To investigate Aβ42 and P-tau levels in cerebrospinal fluid (CSF) of patients with mild cognitive impairment (MCI). Methods CSF of 25 cases of MCI and 14 cases of cognitively normal (CN) were investigated. The CSF levels of Aβ42 and P-tau were detected by ELISA method. Correlation analysis was used to analyze the correlation between P-tau level and MMSE score in MCI. Results The CSF level of Aβ 42 was higher and P-tau was lower in MCI than CN group(P<0.05). P-tau level in MCI was also negatively correlated with MMSE score (P<0.05). Conclusion Aβ42 and P-tau levels in CSF may be valuable biological markers in the diagnosis of MCI. P-tau level in CSF of MCI may be related to the severity of cognitive impairment.关键词
认知障碍/β-淀粉样蛋白42/磷酸化Tau蛋白/脑脊液Key words
Cognitive impairment/Aβ42/P-tau/Cerebrospinal fluid引用本文复制引用
韩丽珠,王文静,褚忠海,吴元波,吴蕾,程昭昭,孙安源..轻度认知障碍患者脑脊液中β-淀粉样蛋白42及磷酸化Tau蛋白的水平检测及意义[J].实用医学杂志,2014,(19):3079-3081,3.基金项目
2013年安徽省卫生厅医学科研课题 （）
