实用医学杂志Issue(19)：3087-3089,3.DOI:10.3969/j.issn.1006-5725.2014.19.018
RhoA和C-myc在胃癌发生发展中的表达及意义
The correlation between RhoA and C-myc expression and the development of gastric cancer
摘要
Abstract
Objective To study the expression of RhoA and C-myc in gastric carcinoma , and to discuss the action in infiltration and metastasis of gastric carcinoma as well as their dependability. Methods RhoA protein expression and C-myc protein expression were detected by immunohistochemical method in 46 cases of gastric carcinoma and 20 cases of normal tissues..RhoA protein expression was compared with clinical pathologic parameters as related to C-myc. Results The positive rate of RhoA,C-myc were significantly higher in gastric carcinoma than in normal tissue (P < 0.05). The expression of RhoA and C-myc were associated with the loss of tumor differentiation, lymph node metastasis and deep invasion (P<0.05). There was a significant correlation between RhoA and C-myc (r=0.62, P<0.05). Conclusions The data suggests that the expression level of RhoA protein was closely related to biological behavior of gastric carcinoma. RhoA and C-myc were possibly both correlated with the infiltration and metastasis of gastric carcinoma.关键词
胃肿瘤/RhoA/C-myc/蛋白表达/免疫组织化学Key words
Stomach neoplasms/RhoA/C-myc/expression of protein/Immunohistochemistry引用本文复制引用
王莉,张旭,刘丽秋,孙玉鸿,朱艳丽,赵玉德,江清林..RhoA和C-myc在胃癌发生发展中的表达及意义[J].实用医学杂志,2014,(19):3087-3089,3.基金项目
黑龙江省教育厅科学技术研究项目 （）
