实用医学杂志Issue(20)：3236-3238,3.DOI:10.3969/j.issn.1006-5725.2014.20.011
降钙素原在诊断社区获得性肺炎和指导抗生素应用中的价值
Role of procalcitonin in diagnosis and antibiotics therapy of community acquired pneumonia
摘要
Abstract
Objective To explore the role of procalcitonin (PCT) in diagnosis and antibiotics therapy of community acquired pneumonia (CAP). Methods A total of 296 patients with CAP and 221 patients with other diseases were included. PCT levels between CAP patients and non-CAP patients, aged and non-aged CAP patients were analyzed. SPSS19.0 was used to make ROC, and the maximum Youden index to determine the optimal cutoff value, the corresponding sensitivity (SEN) and specificity (SPE). Results PCT levels in CAP patients were significantly higher than those in non-CAP (P<0.05). The diagnostic value of PCT in CAP was as follows: the area under the curve (AUC) was 0.67, the optimal cutoff value 0.055 ng/mL and the SEN and SPE were 0.55 and 0.77 respectively. For aged CAP patients, the values were 0.63, 0.055 ng/mL, 0.53 and 0.73 respectively and for non-aged CAP patients, the values were 0.73, 0.085 ng/mL, 0.53 and 0.90 respectively. The days of treatment in PCT-guided antibiotics therapy group were greatly less than those in clinical and radiology-guided antibiotics therapy (P<0.05), while there was no difference on relapse (P>0.05). Conclusion PCT has a high value in diagnosis and antibiotics therapy of CAP.关键词
社区获得性肺炎/降钙素原/诊断/抗生素Key words
Procalcitonin/Community acquired pneumonia/Diagnosis/Antibiotics引用本文复制引用
史家欣,李家树..降钙素原在诊断社区获得性肺炎和指导抗生素应用中的价值[J].实用医学杂志,2014,(20):3236-3238,3.基金项目
国家自然科学基金（编号81300052）；江苏省自然科学基金 （）
