实用医学杂志Issue(20)：3242-3244,3.DOI:10.3969/j.issn.1006-5725.2014.20.013
老年患者细胞色素P4502C19基因多态性与兰索拉唑三联疗法根除幽门螺杆菌疗效的关系
Relationship between the CYP2C19 polymorphism and the efficacy of triple therapy with lansoprazole onHelicobacter pylori infection in elderly patients
摘要
Abstract
Objective To investigate the Relationship between the CYP2C19 polymorphism and the efficacy of triple therapy with lansoprazole on Helicobacter pylori infection. Methods 125 elderly patients diagnosed with H.pylori infection were treated with triple therapy. Polymorphism of CYP2C19 was measured by AS-PCR. 105 young patients were selected as control group. The relationship between the polymorphism and eradication rate were analyzed. Results Among the 125 patients,eradication rate of extensive metabolizer group,internal metabolizer group and poor metabolizer groups was 85.29%,76%and 89.39%, respectively. There was no significant difference between groups (P > 0.05). Eradication rate showed no difference between experimental and control group either (P>0.05)(P>0.05). Conclusion The results suggests that the CYP2C19 polymorphism has no correlation with the eradication rate of Helicobacter pylori infection by triple therapy with lansoprazole in elderly patients.关键词
兰索拉唑/细胞色素P450酶/基因多态性Key words
Iansoprazole/CytochromeP-450 Enzyme/Polymorphism引用本文复制引用
徐俊丽,方瑜洁,刘永国,张明丽,吴松笛,崔亚丽..老年患者细胞色素P4502C19基因多态性与兰索拉唑三联疗法根除幽门螺杆菌疗效的关系[J].实用医学杂志,2014,(20):3242-3244,3.基金项目
陕西自然科学基金研究项目（编号2013JC2-14）；西安市卫生局科研立项 （）
