实用医学杂志Issue(23)：3762-3765,4.DOI:10.3969/j.issn.1006-5725.2014.23.018
乙型肝炎病毒基本核心启动子区热点突变与广西肝癌家族聚集性的相关性
Relationship between hotspot mutations in basic core promoter of hepatitis B virus and familial clustering of hepatocellular carcinoma in Guangxi
摘要
Abstract
Objective To explore the relationship between mutations in basic core promoter (BCP) of hepatitis B virus (HBV) and familial clustering of hepatocellular carcinoma (HCC) in Guangxi. Methods 153 pairs of members with HBsAg-positive were selected and matched from HCC high-incidence families and carcinoma-free families in Guangxi. The BCP genes were amplified and sequenced. Results The hotspot sites of the previous five mutations in BCP were T1762, A1764, G1775, V1753, G1803. In univariant analysis, HBV DNA≥105 copies/mL, T1762, A1764 and V1753 mutations were associated with the HCC high-incidence (P <0.05). The multivariate logistic analysis showed that HBV DNA≥105 copies/mL and A1764 were independent risk factors for it. Conclusion HBV DNA level, the mutations in BCP showed correlations with familial clustering of HCC in Guangxi.关键词
肝炎病毒/乙型/基本核心启动子/突变/肝细胞癌/家族聚集性Key words
Hepatitis B virus/Basic core promoter/Mutation/Hepatocellular carcinoma/Familial clustering引用本文复制引用
石仁芳,吴继周,万裴琦,吴健林,宁秋悦..乙型肝炎病毒基本核心启动子区热点突变与广西肝癌家族聚集性的相关性[J].实用医学杂志,2014,(23):3762-3765,4.基金项目
国家自然科学基金项目（编号30960170）；广西教育厅重点课题 （）
