实用医学杂志Issue(24)：3896-3899,4.DOI:10.3969/j.issn.1006-5725.2014.24.006
阻塞性睡眠呼吸暂停低通气综合征患者的鼻阻力及nCPAP治疗后的影响
Nasal resistance in patients with obstructive sleep apnea hypopnea syndrome and the effect of nCPAP
摘要
Abstract
Objective To observe nasal resistance in healthy adult people and patients with obstructive sleep apnea hypopnea syndrome (OSAHS), comparing the changes in nasal resistance after nCPAP treatment, and to explore the role of nasal resistance in development of OSAHS and the effect of nCPAP on nasal resistance. Methods Detection of nasal resistance was performed in 11 healthy people and 40 patients with OSAHS after completion of polysomnography (PSG). Three weeks after treatment with nCPAP, the patients received polysomnography and detection of nasal resistance again. Results Nasal resistance was higher in patients with OSAHS than healthy people [(0.27 ± 0.9)Pa/(cm3·s) vs. (0.21 ± 0.7)Pa/(cm3·s), t=-2.048, and P<0.05];nasal resistance was not related with age, BMI, neck circumference, waistline, AHI, MinSO2, and ODI (P>0.05). MinSO2, AHI and ODI were markedly improved three weeks after nCPAP therapy (P<0.05). Nasal resistance was increased from (0.27 ± 0.1) Pa/(cm3·s) to (0.43 ± 0.3)Pa/(cm3·s) after treatment (t = -2.733, P < 0.05). Conclusions Increased nasal resistance is one of risk factors for pathogenesis of OSAHS. Nasal resistance is not related with the severity of OSAHS. nCPAP can lead to an elevation in nasal resistance.关键词
阻塞性睡眠呼吸暂停低通气综合征/持续气道内正压通气/鼻阻力Key words
Obstructive sleep apnea hypopnea syndrome/nCPAP/Nasal resistance引用本文复制引用
任莹莹,苏小芬,张挪富..阻塞性睡眠呼吸暂停低通气综合征患者的鼻阻力及nCPAP治疗后的影响[J].实用医学杂志,2014,(24):3896-3899,4.基金项目
广东省高等学校科技创新团队项目 （）
