实用医学杂志Issue(5)：737-740,4.DOI:10.3969/j.issn.1006-5725.2015.05.014
乙肝病毒X蛋白结合蛋白过表达在乳腺癌诊断及预后评估中的意义
The role of HBXIP overexpression in the prognostic evaluation of breast cancer
摘要
Abstract
Objective To investigate the role of HBXIP overexpression in the prognostic evaluation of breast cancer. Methods HBXIP expression was detected in the tissues of 60 breast cancer cases and 15 cases of ductal cancer in situ (DCIS) as well as in the adjacent non-tumorous tissues of 27 cases of breast cancer using EnVision immunohistochemical staining method. The correlations between the HBXIP overexpressions and the clinical pathological characters of the patients with breast cancer were also analyzed. Results The HBXIP proteins showed a major cytoplasmic staining pattern in breast cancer. The strongly positive rate of HBXIP was75.0%(45/60) in breast cancer, significantly higher than in DCIS (20.0%, 3/15) and adjacent non-tumorous tissues (14.8%, 4/27). High-level expression of HBXIP was correlated with late clinical stage, lymph node metastasis and HER-2 positive expression in breast cancer. Conclusions The expression level of HBXIP is closely related to the progression and prognosis of breast cancer. It might be a potential biomarker and therapeutic target of breast cancer.关键词
乳腺肿瘤/HBXIP/免疫组化Key words
Breast Cancer/HBXIP/Immunohistochemistry引用本文复制引用
张华敏,李楠,孙洁,刘双萍..乙肝病毒X蛋白结合蛋白过表达在乳腺癌诊断及预后评估中的意义[J].实用医学杂志,2015,(5):737-740,4.基金项目
国家自然科学基金项目（编号31301065）；吉林省科技厅青年基金项目 （）
