实用医学杂志Issue(5)：743-746,4.DOI:10.3969/j.issn.1006-5725.2015.05.016
血清Fibulin-3水平与脉搏波传导速度在高血压血管重构中的作用
The correlation between Fibulin-3 and Pulse Wave Velocity in patients with hypertension
摘要
Abstract
Objective To investigate the changes and significances of the level of serum Fibulin-3 and correlation between Fibulin-3 and branchial-ankle Pulse Wave Velocity (baPWV) in patients with hypertension. Methods A total of 50 patients with hypertension and 38 healthy people were enrolled finally, whose fasting blood were collected. The levels of Fibulin-3、MMP-9 were detected by enzyme-linked immunosorbent assay. The baPWV was detected by pulse wave velocity automatic analyzer. Results The level of serum Fibulin-3 in hypertension was lower than the control group significantly (P < 0.001). There was no significance of serum MMP-9 in the two groups. The baPWV in hypertension was higher than the control group.Correlations between the level of Fibulin-3 and baPWV were significant (r = -0.324,P = 0.006). While correlations between the level of MMP-9 and baPWV had no significance (r=0.003,P=0.968). Conclusion The level of serum Fibulin-3 and baPWV can be used as index of functional changes in the early stage of hypertensive vascular remodeling, and may be applied for forecasting the organ damage in hypertension.关键词
高血压/血管重构/Fibulin-3/脉搏波传导速度Key words
Hypertension/Vascular remodeling/Fibulin-3/Pulse Wave Velocity引用本文复制引用
林忠伟,王卓,李瑞莹,向定成..血清Fibulin-3水平与脉搏波传导速度在高血压血管重构中的作用[J].实用医学杂志,2015,(5):743-746,4.基金项目
广东省科技厅科研立项（编号2013B021800086）；广东药学院附属第一医院科研立项 （）
