实用医学杂志Issue(9)：1421-1424,4.DOI:10.3969/j.issn.1006-5725.2015.09.011
青岛地区汉族人群脂联素基因多态性与非酒精性脂肪性肝病的相关性
Association between Adiponectin polymorphisms and nonalcoholic fatty liver disease in Han Chinese popu-lation in Qingdao
摘要
Abstract
Objective To investigate the association between the Adiponectin rs266729 and rs2241766 gene polymorphisms and nonalcoholic fatty liver disease in the Han Chinese population residing in Qingdao. Methods Adiponectin rs266729 and rs2241766 gene polymorphisms were genotyped in patients with NAFLD (n = 336) and healthy controls (n = 280) using polymerase chain reaction (PCR). Serum lipid profiles and adiponectin levels were determined using biochemical methods. Statistical analyses were performed using Pearson Chi square test, logistic regression analysis, t test, linear regression analysis. Results We found a significant association between the Adiponectin rs266729 genotype frequencies and allele frequencies between NAFLD pa-tients and controls (χ2= 9.929, P = 0.007; χ2= 9.809, P = 0.002). After adjustment of confounding factor, the rs266729 G allele was associated with an increased risk of NAFLD compared to the C allele (OR = 1.410, 95%CI: 1.082-1.831, P = 0.008) No significant differences were found in the rs2241766 genotype frequencies and allele frequencies between NAFLD population and the controls (OR = 1.410, 95%CI: 1.082-1.831, P = 0.008). Conclusion The Han Chinese in Qingdao carrying the rs266729 G allele are at increased risk of NAFLD.关键词
脂肪肝, 非酒精性/脂联素/基因多态性Key words
Fatty liver, non-alcoholic/Adiponectin/Gene polymorphisms引用本文复制引用
程钰婷,姜曼,辛永宁,安佰全,宣世英..青岛地区汉族人群脂联素基因多态性与非酒精性脂肪性肝病的相关性[J].实用医学杂志,2015,(9):1421-1424,4.基金项目
国家自然科学基金资助项目（编号81170337）；青岛市民生科技计划项目 （）
