实用医学杂志Issue(9)：1428-1430,3.DOI:10.3969/j.issn.1006-5725.2015.09.013
狼疮性肾炎患者血清可溶性白介素7受体的表达及意义
The level of souble interleukin 7receptor in serum from lupus nephritis patients and clinical implication
摘要
Abstract
Objective To investigate the level of soluble interleukin 7 receptor (sIL-7R) in serum of lupus nephritis(LN)patients and evaluate its clinical significance. Methods sIL-7R level in serum of LN patients and healthy controls were measured by ELISA , while total 24 hours urinary protein and complement C3 of LN patients were measured by BN ProSpec. The level of sIL-7R correlation with SLEDAI, total 24 hours urinary protein and complement C3 were analyzed respectively. Results The levelof sIL-7R was higher in serum of LN patients than healthy controls (P < 0.01). Moreover, its expression in serum was increased in LN patients in active stage than in LN patients in stable stage (P < 0.05). The level of sIL-7R was positively assosicated with SLEDAI, total 24 hours urinary protein(P < 0.01, P < 0.05) and negatively with complement C3 (P < 0.05). Conclusion The level of sIL-7R is upregulated in serum in LN patients and correlated with disease activity and progression, so it may be expected to become a potential marker of disease in prediction.关键词
狼疮性肾炎/可溶性白介素7受体Key words
lupus nephritis/souble interleukin 7 receptor引用本文复制引用
柯培锋,彭桉平,王立新,卢欣沂,黄培健..狼疮性肾炎患者血清可溶性白介素7受体的表达及意义[J].实用医学杂志,2015,(9):1428-1430,3.基金项目
广东省科技计划项目（编号粤科规划字［2013］137号）；广东省医学科研基金项目 （）
