实用医学杂志Issue(9)：1434-1438,5.DOI:10.3969/j.issn.1006-5725.2015.09.015
PARVB基因rs5764455多态性与青岛汉族人群非酒精性脂肪性肝病遗传易感性的相关性
Relationship between PARVB rs5764455 polymorphism and non-alcoholic fatty liver disease
摘要
Abstract
Objective To investigate the association between (beta-parvin) PARVB gene rs5764455 polymorphism and susceptibility to non-alcoholic fatty liver disease (NAFLD). Methods A total of 230 patients with NAFLD (NAFLD, n = 230) and 230 control subjects (control, n = 330) were genotyped by PCR and direct sequencing. Clinical information was detected and compared in different groups. Genotypic frequency and gene frequency distribution in the two groups and relative risks to NAFLD susceptibility were assessed statistically , respectively. Results No statistical differences were observed between PARVB gene rs5764455 genotypic frequency with gene frequency distribution and the two groups, respectively (Genotypic frequency χ2 = 0.182, P = 0.913; gene frequency χ2 = 0.180, P = 0.672). Comparing C/T + T/T genotype carrier with C/C genotype carrier, there were no differences concerning the relative risks to NAFLD susceptibility (OR = 1.266, P =0.178;adjusted OR =1.631, P =0.096) before and after adjusting body mass, BMI and so on. In the latter group, there are significant differences in the increases of body mass, BMI, TG, ALT and AST (P < 0.05). Conclusion Non-relationship was observed between PARVB gene rs5764455 polymorphism and the risk of NAFLD in Qingdao Han Chinese.关键词
脂肪肝, 非酒精性/单核苷酸多态性/PARVB基因Key words
Fatty liver/Non-alcoholic fatty liver disease/Gene polymorphism/PARVB引用本文复制引用
耿宁,姜曼,王健,刘洋,姜相君,辛永宁..PARVB基因rs5764455多态性与青岛汉族人群非酒精性脂肪性肝病遗传易感性的相关性[J].实用医学杂志,2015,(9):1434-1438,5.基金项目
国家自然科学基金资助项目（编号81170337／H0304）；青岛市民生科技计划项目 （）
